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| Definition: | A chemical substance produced by the gastric mucosa (stomach) which is necessary for intestinal absorption of vitamin B12.
A deficiency in intrinsic factor can cause pernicious anemia. Deficiencies in intrinsic factor can be caused by surgical removal of the stomach or diseases that cause the gastric mucosa to shrink.
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Review Date: 10/26/2001
Reviewed By: Victoria Kennedy, RN, A.D.A.M. editorial.
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